Implications of m6A modification in autoimmune disorders
نویسندگان
چکیده
منابع مشابه
Recent advances in dynamic m6A RNA modification
The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation a...
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N6-methyladenosine (m6A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m6A modification in neuronal development are still not known. Here, we found that the m6A eraser FTO is enriched in axons and can be locally translated. Axon-specific inhibition of FTO by rhein, or compartmentalized siRNA knockdown of Fto ...
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Identifying disease-causing variants among a large number of single nucleotide variants (SNVs) is still a major challenge. Recently, N6-methyladenosine (m6A) has become a research hotspot because of its critical roles in many fundamental biological processes and a variety of diseases. Therefore, it is important to evaluate the effect of variants on m6A modification, in order to gain a better un...
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Background: Autoimmune diseases (ADs) are chronic conditions characterized by the loss of immunological tolerance to self-antigens. ADs are not rare and show variable patterns in different countries. In this study, we aim to investigate the prevalence of autoimmune disorders and pattern of polyautoimmunity among Iranian children with endocrinopathy. Methods: Overall 45 patients with early-onset...
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Human genetic variation is represented by the genetic differences both within and among populations, and most genetic variants do not cause overt diseases but contribute to disease susceptibility and influence drug response. During the last century, various genetic variants, such as copy number variations (CNVs), have been associated with diverse human disorders. Here, we review studies on the ...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2019
ISSN: 1672-7681,2042-0226
DOI: 10.1038/s41423-019-0307-0